The proteasome as a target for protozoan parasites
نویسندگان
چکیده
منابع مشابه
Polyamine metabolism as chemotherapeutic target in protozoan parasites.
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine ...
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In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development. The catalytic heart of these complexes, the 20S proteasome, is highly conserved in bacteria, ...
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ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Targets
سال: 2019
ISSN: 1472-8222,1744-7631
DOI: 10.1080/14728222.2019.1685981